Publications

Zou Z; Wei J; Chen Y; Kang Y; Shi H; Yang F; Shi Z; Chen S; Zhou Y; Sepich-Poore C; Zhuang X; Zhou X; Jiang H; Wen Z; Jin P*, Luo C*, He C*. FMRP phosphorylation modulates neuronal translation through YTHDF1. Mol Cell . 2023 Dec 7;83(23):4304-4317.e8. doi: 10.1016/j.molcel.2023.10.028. Epub 2023 Nov 9. PMID: 37949069 (*: Co-Corresponding authors)

Liu Q, Zhang K, Kang Y, Li Y, Deng P, Li Y, Tian Y, Sun Q, Tang Y, Xu K, Zhou Y, Wang JL, Guo J, Li JD, Xia K, Meng Q, Allen EG, Wen Z, Li Z, Jiang H, Shen L, Duan R, Yao B, Tang B*, Jin P*, Pan Y*. (2022) Expression of expanded GGC repeats within NOTCH2NLC causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease. Science Advances 8(47):eadd6391. Epub 20221123. doi: 10.1126/sciadv.add6391. PubMed PMID: 36417528. (*: Co-Corresponding authors)

Kong HE; Lim J; Linsalata A; Kang Y; Malik I; Allen EG; Cao Y; Shubeck L; Johnston R; Huang Y; Gu Y; Guo X; Zwick ME; Qin Z; Wingo TS; Juncos J; Nelson DL; Epstein MP; Cutler DJ; Todd PK; Sherman SL; Warren ST; Jin P. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Proc Natl Acad Sci U S A . 2022 May 31;119(22):e2118124119. doi: 10.1073/pnas.2118124119. Epub 2022 May 26. PMID: 35617426

Kang Y, Zhou Y, Li Y, Han Y, Xu J, Niu W, Li Z, Liu S, Feng H, Huang W, Duan R, Xu T, Raj N, Zhang F, Dou J, Xu C, Wu H, Bassell GJ, Warren ST, Allen EG, Jin P*, Wen Z*.  A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies. Nature Neuroscience . 2021 Oct;24(10):1377-1391. doi: 10.1038/s41593-021-00913-6. Epub 2021 Aug 19. PMID: 34413513 (*: Co-Corresponding authors)

Kim H, Kang Y, Li Y, Chen L, Lin L, Johnson ND, Zhu D, Robinson MH, McSwain L, Barwick BG, Yuan X, Liao X, Zhao J, Zhang Z, Shu Q, Chen J, Allen EG, Kenney AM, Castellino RC, Van Meir EG, Conneely KN, Vertino PM, Jin P*, Li J*. (2021) Ten-eleven translocation protein 1 modulates medulloblastoma progression. Genome Biology, 22(1):125. (*: Co-Corresponding authors)

Shafik AM; Zhang F; Guo Z; Dai Q; Pajdzik K; Li Y; Kang Y; Yao B; Wu H; He C; Allen EG; Duan R; Jin P. N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer’s disease. Genome Biology . 2021 Jan 5;22(1):17. doi: 10.1186/s13059-020-02249-z. PMID: 33402207

Cheng Y, Sun M, Chen L, Li Y, Lin L, Yao B, Li Z, Wang Z, Chen J, Miao Z, Xin N, Huang L, Allen EG, Wu H, Xu X, Jin P. (2018) Distinct roles of Ten-eleven translocation protein 1 and 2 in response to environmental stress. Cell Reports, 25: 3194-3203.

Pan F, Wingo TS, Zhao Z, Gao R, Makishima H, Qu G, Lin L, Yu M, Ortega JR, Wang J, Nazha A, Chen L, Yao B, Liu C, Chen S, Weeks O, Ni H, Phillips BL, Huang S, Wang J, He C, Li GM, Radivoyevitch T, Aifantis I, Maciejewski JP, Yang FC, Jin P*, Xu M. (2017) Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells. Nature Communications, 8:15102. (*: Co-Corresponding authors)

Oh Y, Zhang F, Wang Y, Lee EM, Choi IY, Lim H, Mirakhori F, Li R, Huang L, Xu T, Wu H, Li C, Qin CF, Wen Z, Wu QF, Tang H*, Xu Z*, Jin P*, Song H, Ming GL*, Lee G. (2017) Zika virus directly infects peripheral neurons and induces cell death. Nature Neuroscience, 20(9):1209-12. (*: Co-Corresponding authors)

Li X, Yao B, Chen L, Kang Y, Li Y, Cheng Y, Li L, Lin L, Wang Z, Wang M, Pan F, Dai Q, Zhang W, Wu H, Shu Q, Qin Z, He C, Xu M, Jin P. (2017) Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis. Nature Communications, 8:15903. PMC5493768

​Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P*, Song H*. (2016). Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell, 61, 153-160. (*: Co-Corresponding authors) PMC4779955

Zhao Z, Chen L, Dawlaty MM, Pan F, Weeks O, Zhou Y, Cao Z, Shi H, Wang J, Lin L, Chen S, Yuan W, Qin Z, Ni H, Nimer SD, Yang FC, Jaenisch R, Jin P*, Xu M*. (2015) Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice. Cell Reports, 13: 1692-1704. (*: Co-Corresponding authors) PMC4764044

Myrick, L.K., Deng, P-Y., Hashimoto, H., Oh, Y.M., Cho, Y., Poidevin, M.J., Suhl, J.A., Visootsak, J., Cavalli, V., Jin, P., Cheng, X., Warren, S.T., and Klyachko, V.A. (2014) An independent role for presynaptic FMRP revealed by an FMR1 missense mutation associated with intellectual disability and seizures. Proceedings of the National Academy of Sciences, 112:949-56.

Huang, H., Li, Y., Szulwach, K.E., Zhang, G., Jin, P.*, and Chen, D.* (2014) AGO3 Slicer Activity Regulates Mitochondria-Nuage Localization of Armitage and piRNA Amplification. Journal of Cell Biology, 206, 217-230. (*: Co-Corresponding authors)

Wang, T., Wu, H., Li, Y., Szulwach, K.E., Lin, L., Li, X., Chen, I.P., Goldlust, I.S., Chamberlain, S.J., Ananiev, G., Mowrey, J., Han, J.W., Yoon, Y., Rudd, M.K., Song, C.X., He, C., Chang, Q., Warren, S.T., and Jin, P. (2013) Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency. Nature Cell Biology, 15: 700-711. PMC3998089

Xu, Z., Poidevin, M., Li, X., Li, Y., Shu, L., Nelson, D.L., Li, H., Gearing, M., Wingo, T.S., and Jin, P. (2013) Expanded Hexanucleotide GGGGCC Repeat RNA Associated with ALS/FTD Causes Neurodegeneration. Proceedings of the National Academy of Sciences, 110: 7778-7783. PMC3651485

Song, C.X., Szulwach, K.E., Dai, Q., Fu, Y., Mao, S.Q., Lin, L., Street, C., Li, Y., Poidevin, M., Wu, H., Gao, J., Liu, P., Li, L., Xu, G.L., Jin, P.*, and He, C.* Genome-wide Profiling of 5-Formylcytosine reveals its roles in epigenetic priming. Cell, 153: 678-691. (*:Co-Corresponding authors) PMC3657391

Li, Y., Lin, L., Li, Z., Ye, X., Xiong, K., Aryal, B., Xu, Z., Paroo, Z., Liu, Q., He, C., and Jin, P. (2012) Iron Homeostasis Regulates the Activity of the MicroRNA Pathway through Poly(C)-Binding Protein 2. Cell Metabolism, 15, 895-904. PMC3613991

Yu, M., Hon, G.C., Szulwach, K.E., Song, C.X., Zhang, L., Kim, A., Li, X., Dai, Q., Shen, Y., Park, B., Min, J.H., Jin, P. *, Ren, B. *, and He. C. * (2012) Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome. Cell, 149: 1368-1380. (*: Co-Corresponding authors).

Song, C.X., Szulwach, K.E., Fu, Y., Dai, Q., Yi, C., Li, X., Li, Y., Chen, C.H., Zhang, W., Jian, X., Wang, J., Zhang, L., Looney, T.J., Zhang, B., Godley, L.A., Hicks, L.M., Lahn, B.T., Jin, P.*, and He, C*. (2011) Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nature Biotechnology, 29(1): 68-72. (*: Co-Corresponding authors).

Szulwach, K.E., Li, X., Li, Y., Song, C.X., Wu, H., Dai, Q., Irier, H., Upadhyay, A.K., Gearing, M., Levey, A.I., Vasanthakumar, A., Godley, L.A., Chang, Q., Cheng, X., He, C. and Jin, P. (2011) 5-hydroxymethylcytosine-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nature Neuroscience, 14: 1607-1616. PMC3292193

Szulwach K. E., Li, X., Smrt, R.D., Li, Y., Luo, Y., Lin, L., Satistevan, N.J., Li, W. Zhao, X., and Jin, P. (2010) Cross talk between microRNA and epigenetic regulation in adult neurogenesis. Journal of Cell Biology, 189, 127-141. PMC2854370

Chang, S., Bray, S.M., Li, Z., Zarnescu, D.C., He, C., Jin, P., and Warren, S.T. (2008). Identification of small molecules rescuing morphological, biochemical and behavioral phenotypes of fragile X syndrome in Drosophila. Nature Chemical Biology, 4, 256-263.

Sofola, O.A.*, Jin, P.* (equal contribution), Qin, Y., Duan, R., Liu, H., de Haro, M., Nelson, D.L., and Botas, J. (2007). RNA binding proteins hnRNP A2/B1 and CUGBP1 suppress Fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS. Neuron, 16, 565-571. PMC2215388

Shan, G.*, Li, Y.* (*Equal Contribution), Zhang, J., Li, W., Szulwach, K., Duan, R., Faghihi, M.A., Khalil, A., Lu, L., Paroo, Z., Chan, A.W.S., Shi, Z., Liu, Q., Wahlestedt, C., He, C., and Jin, P. (2008). A small molecule enhances RNA interference and promotes microRNA processing. Nature Biotechnology, 8, 933-940. PMC2831467

Jin, P.*, Duan, R., Qurashi, A., Qin, Y., Tian, D., Rosser, T.C., Liu, H., Feng, Y., and Warren, S.T.* (2007). Pur a binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of Fragile X Tremor/Ataxia Syndrome. Neuron, 16, 556-564. (*: Co-Corresponding authors)